It was reported at the time of her death that the DeVos family had made donations of "more than $1.2 billion over the years". The Richard and Helen DeVos Foundation was a major focus of the DeVos family philanthropy. Helen was especially active in charity to children, education, and music. The Helen DeVos Children's Hospital in Grand Rapids is named after her. Other named buildings include Richard and Helen DeVos Japanese Garden at Frederik Meijer Gardens, the Richard and Helen DeVos Fieldhouse at Hope College as well as the theater there named for her parents, George and Wilma Van Wesep. The Helen DeVos Presidential Scholarship for study of music and the arts was created at Grand Valley State University.
Helen DeVos Children's Hospital is a pediatric hospital in Grand Rapids, Michigan, and a division of Spectrum Health. It is named for Helen DeVos, wife of Amway founder Richard DeVos, a major donor